The Philadelphia chromosome and galactose-1-phosphate uridyl transferase.
نویسندگان
چکیده
\ ‘7ith the technical assistance of Jean Downes T FIE OCCURRENCE OF chromosomal abnormalities in humans provides a method for investigating the function of specific chromosomes. In trisomy-21 many studies have l)een carried out in an attempt to evaluate the functions of this autosome.l h Another abnormality of the 21 group is found in patients with chronic myelogenous leukemia. In these cases, one of these two autosomes is abnormally small and has been designated the Philadelphia or Ph’ chromosome.7M Elevated activity of the enzyme galactose-1-phosphate uridyl transferase has been reported in the blood of patients with mongolism.1 Therefore, this enzyme was investigated in the blood of patients with the Ph’ chromosome in order to study its relation to chromosome No. 21.
منابع مشابه
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عنوان ژورنال:
- Blood
دوره 29 5 شماره
صفحات -
تاریخ انتشار 1967